Baseline physical and routine checks in the merged Package E checklist.
| Check item | Check content | Clinical value | Reference price (USD) |
|---|---|---|---|
Physician physical examination | General measurements: height, weight, waist-to-hip ratio. Internal medicine: heart, lungs, liver, spleen, and related systems. Surgery: breasts, thyroid, digital rectal examination, etc. Ophthalmology: visual acuity, color vision. ENT: external auditory canals, nose, pharynx, etc. Dentistry: oral health status and treatment planning overview. | The most direct and fundamental assessment of overall physical status. | $9 |
Routine laboratory | *Complete blood count (CBC) + high-sensitivity C-reactive protein (hs-CRP); urinalysis | Screens for hematologic disorders, infectious disease, urinary tract infection and renal disease. | $7 + $4 |
Urinary microalbumin quantification (random urine) | Urinary microalbumin quantification (random urine) | A sensitive indicator of glomerular disease and renal tubular injury. | $7 |
Creatinine (random urine) | Creatinine (random urine) | Evaluates kidney function and reflects muscle metabolism. | $1 |
Stool routine examination + fecal occult blood | Stool routine examination + fecal occult blood | Screens for gastrointestinal infection and lesions. | $3 |
*Erythrocyte sedimentation rate (ESR) | Erythrocyte sedimentation rate (ESR) | Helps screen for hematologic, tuberculosis-related, rheumatologic, oncologic and immune-mediated disorders. | $1 |
Laboratory and specialty markers in the merged Package E checklist.
| Check item | Check content | Clinical value | Reference price (USD) |
|---|---|---|---|
*Comprehensive biochemistry panel | Comprehensive biochemical profile | Assesses liver function, kidney function, blood glucose, blood lipids, proteins, uric acid, electrolytes and overall systemic metabolism. | $32 |
α-L-Fucosidase (AFU) | α-L-Fucosidase (AFU) assay | An emerging hepatocellular carcinoma marker supporting early diagnosis and screening in higher-risk cohorts. | $2 |
*Homocysteine | Homocysteine | Helps predict risk of cardiovascular events and stroke. | $7 |
*Small dense low-density lipoprotein (sdLDL) | Small dense low-density lipoprotein (sdLDL) | Assists cardiovascular risk stratification. | $8 |
*Glycated hemoglobin (HbA1c) | Glycated hemoglobin (HbA1c) | Reflects average blood glucose control over approximately the past 2–3 months; supports diabetes monitoring. | $4 |
*Glycated albumin (GA) | Glycated albumin (GA) | Reflects glycemic control over approximately the past 2–4 weeks; useful for short-term glucose assessment. | $10 |
*Free fatty acids | Free fatty acids | Evaluates lipid metabolism. | $1 |
*Cystatin C | Cystatin C | Assesses renal function. | $6 |
*Insulin | Fasting insulin | Evaluates pancreatic beta-cell insulin secretion. | $6 |
*Vitamin B12 | Vitamin B12 | Screens for megaloblastic anemia; participates in homocysteine metabolism and aids cardiovascular risk factor assessment. | $5 |
*Folate | Folate | Screens cardiovascular risk factors and evaluates nutritional status. | $6 |
*Cortisol | Cortisol | Screens disorders such as exogenous/simple obesity-related patterns, adrenal hyperplasia and hypercortisolism. | $3 |
*Thyroid function panel (seven tests) | FT3, FT4, TT3, TT4, anti-TG, anti-TPO, TSH | Evaluates thyroid function. | $38 |
*Serum iron | Serum iron | Screens iron deficiency states and anemia. | $3 |
*25-Hydroxyvitamin D [25(OH)D] | 25-Hydroxyvitamin D | Supports evaluation of bone and mineral metabolism. | $8 |
*Parathyroid hormone (PTH) | Parathyroid hormone (PTH) | Primarily used to assess parathyroid function. | $8 |
*Apolipoproteins | ApoA, ApoB | Assesses apolipoprotein levels and lipid transport. | $8 |
*Creatine kinase-MB isoenzyme (CK-MB) | Creatine kinase-MB isoenzyme (CK-MB) | Screens myocarditis, myocardial infarction and other cardiac conditions. | $9 |
*Serum protein electrophoresis | Serum protein electrophoresis | Helps screen for hematologic, rheumatologic, oncologic and immune-related disorders. | $3 |
*Oxidized low-density lipoprotein (OxLDL) | Oxidized low-density lipoprotein cholesterol | Supports prevention, monitoring and early diagnosis of cardiovascular disease and lipid metabolism disorders. | $4 |
*Apolipoprotein E (apoE) | Apolipoprotein E (apoE) | Associated with dyslipidemia, Alzheimer disease, atherosclerosis, coronary artery disease, Parkinson disease and stroke. | $6 |
*Human epididymis protein 4 (HE4) Applicability: Female only | Human epididymis protein 4 (HE4) | Supports early ovarian cancer detection, differential diagnosis, treatment monitoring and prognostic assessment. | $8 |
*Expanded tumor markers (add-on) | CA125, NSE | Additional screening for frequent solid tumors. | $15 |
*Thyrotropin receptor antibodies (TRAb) | Thyrotropin receptor antibody assay | Important ancillary test for Graves disease and autoimmune thyroid disorders. | $6 |
*Hepatic fibrosis panel (four biomarkers) | Hepatic fibrosis four-marker panel | Supports diagnosis and staging of hepatic fibrosis. | $23 |
*Bone turnover markers (three tests) | Osteocalcin, β–cross-linked C-telopeptide of type I collagen (β-CTX), total procollagen type I N-terminal propeptide (Total-P1NP) | Integrated evaluation of metabolic bone disease, bone turnover and systemic disorders affecting bone. | $31 |
N-acetyl-β-D-glucosaminidase (NAG) | Urinary NAG | Elevated urinary NAG is an early sign of renal injury and a sensitive marker of tubular damage. | $2 |
α1-Microglobulin (α1-MG) | Urinary α1-microglobulin (α1-MG) | Early marker of proximal tubular dysfunction. | $7 |
*Coagulation panel (four tests) | PT, APTT, fibrinogen, TT | Evaluates intrinsic and extrinsic coagulation pathways. | $13 |
*Allergen-specific IgE panel | Screening IgE antibodies to fourteen allergens | Identifies atopic sensitization patterns. | $79 |
*Rheumatoid and inflammatory arthritis serology | ASO, CRP, rheumatoid factor (RF) | Supports rheumatic disease diagnosis and monitors inflammatory activity. | $13 |
*Thrombelastography (TEG)—standard assay | Thrombelastography, routine assay | Global assessment of clot formation and dissolution; stratifies thrombotic versus bleeding tendencies. | $17 |
*Expanded tumor markers (add-on) | CA72-4 | Additional screening for gastrointestinal and other malignancies. | $8 |
*Ceruloplasmin | Ceruloplasmin (CER) | Aids evaluation of inflammatory, hepatic, renal and malignant conditions. | $3 |
*T lymphocyte subsets / immunophenotype | T-cell, NK-cell and related immune subsets | Assesses cellular immunity relevant to autoimmune and infectious disorders. | $84 |
*Secondary hypertension biomarker panel (four hormones) | Renin-angiotensin-aldosterone axis–related assays (clinic-standard four-test panel) | Helps differentiate secondary causes of hypertension. | $28 |
*Apolipoprotein A-II (apoA-II) | Apolipoprotein A-II (apoA-II) | Correlates with cardiovascular and oncology risk pathways. | $4 |
*Tumor marker add-on—CA15-3 | Carbohydrate antigen 15-3 (CA15-3) | Augments broad tumor-marker screening programmes (male 15-marker profile; female 13-marker profile context per packaged panel). | $8 |
*B-type natriuretic peptide (BNP) | B-type natriuretic peptide (BNP) | Biochemical support for diagnosing and stratifying heart failure. | $25 |
*Epstein-Barr virus (EBV) serology | EBV antibody profile | Evaluates latent EBV infection and supports nasopharyngeal carcinoma risk assessment. | $8 |
*Trace elements and toxic metals panel (seven tests) | Serum: copper, zinc, magnesium; urine: lead, mercury, arsenic | Screens essential trace-element balance and toxic heavy-metal exposure markers. | $84 |
*Reproductive hormone panel | Male: prolactin (PRL), testosterone (T), estradiol (E2), FSH, LH; female: prolactin (PRL), progesterone (P), testosterone (T), estradiol (E2) | Evaluates pituitary-ovarian (or pituitary-testicular) axis function. | Male $29 / Female $24 |
Multitarget fecal FIT-DNA assay | Combined fecal DNA mutation, promoter methylation and immunochemical fecal occult blood assay | Multidimensional gastrointestinal risk stratification targeting precancerous lesions and early-stage colorectal cancer—an alternative when sedated colonoscopy is declined or poorly tolerated. | $276 |
Disposable supplies | Vacuum blood collection tubes | Standard phlebotomy consumables. | $1 |
Imaging, ultrasound and functional tests in the merged Package E checklist.
| Check item | Check content | Clinical value | Reference price (USD) |
|---|---|---|---|
Electrocardiogram (ECG) | Computerized 12-lead electrocardiogram | Assists diagnosis of cardiac disease. | $6 |
Chest posteroanterior radiograph—digital DR (no films) | Digital radiography chest posteroanterior view (ribs not included) | Assesses pulmonary parenchyma and major thoracic structures. | $10 |
*Color Doppler ultrasound: liver, gallbladder, spleen and pancreas | Liver, gallbladder, spleen, pancreas | Evaluates abdominal organ anatomy and pathology. | $16 |
Thyroid color Doppler ultrasound | Thyroid color Doppler ultrasound | Screens thyroid disease. | $16 |
Male urinary tract color Doppler ultrasound (full bladder required) Applicability: Male only | Color Doppler ultrasound of both kidneys, ureters, urinary bladder and prostate | Evaluates anatomy and pathology of the kidneys, ureters, bladder and prostate. | $16 |
Breast color Doppler ultrasound Applicability: Female only | Breast color Doppler ultrasound | Screens benign and malignant breast conditions. | $16 |
Bone densitometry | Quantitative ultrasound bone densitometry | Assesses bone mineral status and screens for osteoporosis and bone loss. | $14 |
Body metabolism dynamic composition analysis ×2 | Body metabolism dynamic composition analysis | Dynamic screening for visceral adiposity patterns and cardiometabolic risk, with osteoporosis risk context. | $35 |
*Urea breath test—¹³C (H. pylori) | Helicobacter pylori testing (urea breath) | Screens active H. pylori infection. | $14 |
Pulmonary function testing | Spirometry and ventilatory function assessment | Characterizes baseline lung mechanics and airflow. | $18 |
Fundus photography | Color fundus photography | Screens retinal, macular, optic disc and retinal vascular disease. | $6 |
Arterial stiffness assessment | Pulse wave velocity / arterial elasticity testing | Non-invasive assessment of vascular stiffness and systemic atherosclerotic burden. | $33 |
Carotid artery color Doppler ultrasound | Bilateral carotid color Doppler ultrasound | Assesses carotid atherosclerosis and supports coronary artery disease risk stratification. | $23 |
Transthoracic echocardiography | Color Doppler echocardiography | Evaluates cardiac structure and function. | $49 |
***Low-dose screening chest CT + AI analysis (no films) | Low-dose screening chest CT with artificial-intelligence-assisted reading | Detailed lung imaging with AI-augmented nodule detection and characterization. | $56 |
Cervical spine AP and lateral radiographs—digital DR (no films) | Digital radiography cervical spine AP and lateral views | Assesses cervical alignment, vertebrae, discs, foraminal zones and ligament-related changes. | $10 |
Ophthalmology package C | Visual acuity; color vision; slit-lamp anterior segment examination; intraocular pressure | Screens gross visual function, color deficiency, anterior segment pathology, and elevated IOP glaucoma-related risk. | $3 |
Lumbar spine AP and lateral radiographs—digital DR (no films) | Digital radiography lumbar spine AP and lateral views | Assesses lumbar alignment and structural changes. | $10 |
Gender-specific and gynecology pathways in the merged Package E checklist.
| Check item | Check content | Clinical value | Reference price (USD) |
|---|---|---|---|
Gynecologic pelvic ultrasound Applicability: Female only | Transabdominal gynecologic color Doppler ultrasound (full bladder) or transvaginal color Doppler ultrasound; uterus, adnexa, ovaries | Evaluates pelvic organ anatomy and pathology. | Transabdominal $16 / **Transvaginal $24** |
**Gynecologic examination Applicability: Female with sexual history | Speculum examination and bimanual pelvic examination | Standard gynecologic clinical examination. | $2 |
**Immunofluorescence staining with diagnostic interpretation Applicability: Female with sexual history | Fluorescent assay of vaginal secretions | Screens for candidiasis, bacterial vaginosis and trichomoniasis. | $19 |
**ThinPrep cervical cytology (TCT) Applicability: Female with sexual history | Liquid-based thin-layer cervical cytology | Evaluates cervical cell morphology and supports cervical cancer screening. | $28 |
**HPV DNA assay (13 high-risk genotypes) Applicability: Female with sexual history | Human papillomavirus (HPV) DNA testing | Identifies high-risk HPV infection to support prevention and early management of cervical neoplasia. | $31 |
*Tumor marker panel | CEA, AFP, SCC, PGI, PGII, CA19-9, cytokeratin 19 fragment (Cyfra 21-1), ProGRP, ferritin (Ferritin); males additionally TPSA, FPSA | Screens common solid tumors with added prostate cancer markers for male patients. | $79 + male prostate panel $15 |
**Candida testing (secretions) Applicability: Female with sexual history | Vaginal secretion analysis | Screens for Candida genital tract infection. | $22 |
**Gardnerella vaginalis testing (secretions) Applicability: Female with sexual history | Vaginal secretion analysis | Screens for Gardnerella vaginalis–associated vaginosis. | $22 |
Optional upgrades available on request.
| Check item | Check content | Clinical value | Reference price (USD) |
|---|---|---|---|
*Reproductive hormones—individual test | Follicle-stimulating hormone (FSH) | Evaluates hypothalamic-pituitary-gonadal axis function (recommended blood draw cycle days 3–5 when applicable). | $6 |
*Reproductive hormones—individual test | Luteinizing hormone (LH) | Evaluates hypothalamic-pituitary-gonadal axis function (recommended blood draw cycle days 3–5 when applicable). | $5 |
*Magnetically guided capsule gastroscopy incl. small bowel | Magnetically controlled capsule endoscopy system (appointment required) | Screens mucosal neoplasia of stomach and small bowel (appointment scheduling required). | $672 |
TWIST1 gene methylation assay—department of pathology | Urinary exfoliated cell TWIST1 promoter methylation testing | Detects aberrant TWIST1 methylation in shed urothelial DNA to aid bladder cancer diagnosis. | $115 |
*Germline BRCA1/BRCA2 sequencing—blood sample | Full coding sequences plus splice sites, promoters and untranslated regions (UTRs) for BRCA1 and BRCA2 | Screens hereditary susceptibility to breast, ovarian, prostate and pancreatic malignancies—genetic test; duplication not required elsewhere in the itinerary. | $529 |
